tailieunhanh - Báo cáo y học: "ranulocyte-macrophage colony-stimulating factor as an immune-based therapy in HIV infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: ranulocyte-macrophage colony-stimulating factor as an immune-based therapy in HIV infection. | Journal of Immune Based Therapies and Vaccines BioMed Central Review Granulocyte-macrophage colony-stimulating factor as an immune-based therapy in HIV infection Pierre Antoine Brown1 and Jonathan B Angel 1 2 Open Access Address department of Medicine University of Ottawa 501 Smyth Box 210 Ottawa Canada K1H 8L6 and division of Infectious Diseases Ottawa Hospital - General Campus 501 Smyth Room G-12 Ottawa Canada K1H 8L6 Email Pierre Antoine Brown - brownpa@ Jonathan B Angel - jangel@ Corresponding author Published 18 May 2005 Received 04 February 2005 Accepted 18 May 2005 Journal of Immune Based Therapies and vaccines 2005 3 3 doi 14768518-3-3 This article is available from http content 3 l 3 2005 Brown and Angel licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The HIV AIDS epidemic continues to spread despite more than 20 years of significant research and major advances in its treatment. The introduction of highly active antiretroviral therapy in recent years has significantly improved disease treatment with a dramatic impact in HIV AIDS associated morbidity and mortality in countries which have access to this therapy. Despite these advances such therapies are imperfect and other therapeutic modalities including immune-based therapies are being actively sought. Potential benefits of immune-based therapies include 1 the improvement of HIV-specific immunity to enhance control of viral replication 2 the improvement of other aspects of host immunity in order to prevent or delay the development of opportunistic infections and 3 the potential to purge virus from cellular reservoirs which are sustained despite the effects of potent antiretroviral therapy. .