tailieunhanh - Báo cáo y học: " Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village. | van der Loeff et al. Retrovirology 2010 7 46 http content 7 1 46 gtr RETROVIROLOGY RESEARCH Open Access Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village Maarten F Schim van der Loefft1 Natasha Larke42 Steve Kaye 1 Neil Berry3 Koya Ariyoshi4 Abraham Alabi1 Carla van Tienen1 Aleksandra Leligdowicz1 Ramu Sarge-Njie1 Zacharias da Silva5 Assan Jaye1 Dominique Ricard1 Tim Vincent5 Sarah Rowland Jones1 Peter Aaby5 Shabbar Jaffar2 and Hilton Whittle 1 Abstract Background There have been no previous studies of the long-term survival and temporal changes in plasma viral load among HIV-2 infected subjects. Methods 133 HIV-2 infected and 158 HIV-uninfected subjects from a rural area in North-west Guinea-Bissau West Africa were enrolled into a prospective cohort study in 1991 and followed-up to mid-2009. Data were collected on four occasions during that period on HIV antibodies CD4 and HIV-2 plasma viral load. Results Median age interquartile range IQR of HIV-2 infected subjects at time of enrollment was 47 36 60 years similar to that of HIV-uninfected control subjects 49 38 62 p . Median IQR plasma viral load and CD4 percentage were 347 50 4 300 copies ml and 29 22 35 respectively. Overall loss to follow-up to assess vital status was small at and for HIV-2 infected and uninfected subjects respectively. An additional 17 and 16 of HIV-2 infected and uninfected subjects respectively were censored during follow-up due to infection with HIV-1. The mortality rate per 100 person-years 95 CI was among HIV-2 infected subjects compared to among HIV-uninfected age-sex adjusted rate ratio p representing a 2-fold excess mortality rate associated with HIV-2 infection. Viral load measurements were available for 98 78 77 and 61 HIV-2 infected subjects who were alive and had not become super-infected with HIV-1 in 1991 1996 2003 and 2006 respectively.