tailieunhanh - Báo cáo y học: "Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study. | Available online http content 10 2 R53 Research Procalcitonin lipopolysaccharide-binding protein interleukin-6 and C-reactive protein in community-acquired infections and sepsis a prospective study Shahin Gaini1 Ole Gr sboll Koldkj r2 Court Pedersen1 and Svend Stenvang Pedersen1 Department of Infectious Diseases Odense University Hospital Odense Denmark 2Department of Clinical Biochemistry Sonderborg Hospital Sonderborg Denmark Corresponding author Shahin Gaini Received 9 Jan 2006 Revisions requested 25 Jan 2006 Revisions received 1 0 Feb 2006 Accepted 24 Feb 2006 Published 28 Mar 2006 Critical Care 2006 10 R53 doi cc4866 This article is online at http content 10 2 R53 2006 Gaini et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Clinicians are in need of better diagnostic markers in diagnosing infections and sepsis. We studied the ability of procalcitonin lipopolysaccharide-binding protein IL-6 and C-reactive protein to identify patients with infection and sepsis. Methods Plasma and serum samples were obtained on admission from patients with suspected community-acquired infections and sepsis. Procalcitonin was measured with a time-resolved amplified cryptate emission technology assay. Lipopolysaccharide-binding protein and IL-6 were measured with a chemiluminescent immunometric assay. Results Of 194 included patients 106 had either infection without systemic inflammatory response syndrome or sepsis. Infected patients had significantly elevated levels of procalcitonin lipopolysaccharide-binding protein C-reactive protein and IL-6 compared with noninfected patients P . In a receiver-operating characteristic curve analysis