tailieunhanh - Báo cáo y học: "The xenotropic murine leukemia virus-related retrovirus debate continues at first international workshop."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The xenotropic murine leukemia virus-related retrovirus debate continues at first international workshop. | Stoye et al. Retrovirology 2010 7 113 http content 7 1 113 RETROVIROLOGY REVIEW Open Access The xenotropic murine leukemia virus-related retrovirus debate continues at first international workshop Jonathan P Stoye1 Robert H Silverman2 Charles A Boucher3 Stuart FJ Le Grice4 Abstract The 1st International Workshop on Xenotropic Murine Leukemia Virus-Related Retrovirus XMRV co-sponsored by the National Institutes of Health The Department of Health and Human Services and Abbott Diagnostics was convened on September 7 8 2010 on the NIH campus Bethesda MD. Attracting an international audience of over 200 participants the 2-day event combined a series of plenary talks with updates on different aspects of XMRV research addressing basic gammaretrovirus biology host response association of XMRV with chronic fatigue syndrome and prostate cancer assay development and epidemiology. The current status of XMRV research concerns among the scientific community and suggestions for future actions are summarized in this meeting report. Introduction In 2006 Urisman et al. 1 described the identification and characterization of a novel gammaretrovirus xeno-tropic murine leukemia virus-related virus XMRV in a small number of prostate cancers. Subsequent studies of Schlaberg et al. 2 suggested that XMRV might have a broader distribution and was present in both prostate cancer patients and benign controls. XMRV is very closely related to endogenous proviruses found in inbred laboratory mice some of which cause lymphoma and other diseases in mice. Due to the lack of functional receptor Xpr1 this virus does not replicate in most inbred mice but grows well in human prostate cancer cell lines. Interest in XMRV has recently intensified following the work of Lombardi et al. 3 who detected XMRV in chronic fatigue syndrome CFS patients in clusters of cases in Nevada and Florida-South Carolina. Virus could be detected through both antibodies in serum and proviral DNA in .