tailieunhanh - Báo cáo y học: "Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to human"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humans. | RETROVIROLOGY Two distinct variants of simian foamy virus in naturally infected mandrills Mandrillus sphinx and cross-species transmission to humans Mouinga-Ondémé et al. Mouinga-Ondémé et al. Retrovirology 2010 7 105 http content 7 1 105 14 December 2010 2 BioMed Central Mouinga-Ondémé et al. Retrovirology 2010 7 105 http content 7 1 105 RESEARCH RETROVIROLOGY Open Access Two distinct variants of simian foamy virus in naturally infected mandrills Mandrillus sphinx and cross-species transmission to humans 1 2 113 4 Augustin Mouinga-Ondémé Edouard Betsem Mélanie Caron Maria Makuwa Bettina Sallé Noemie Renault 45 5 2 1 6 All Saib Paul Telfei Preston Marx Antoine Gessain Miidad Kazanji Abstract Background Each of the pathogenic human retroviruses HIV-1 2 and HTLV-1 has a nonhuman primate counterpart and the presence of these retroviruses in humans results from interspecies transmission. The passage of another simian retrovirus simian foamy virus SFV from apes or monkeys to humans has been reported. Mandrillus sphinx a monkey species living in central Africa is naturally infected with SFV. We evaluated the natural history of the virus in a free-ranging colony of mandrills and investigated possible transmission of mandrill SFV to humans. Results We studied 84 semi-free-ranging captive mandrills at the Primate Centre of the Centre International de Recherches Médicales de Franceville Gabon and 15 wild mandrills caught in various areas of the country. The presence of SFV was also evaluated in 20 people who worked closely with mandrills and other nonhuman primates. SFV infection was determined by specific serological Western blot and molecular nested PCR of the integrase region in the polymerase gene assays. Seropositivity for SFV was found in 70 84 83 captive and 9 15 60 wild-caught mandrills and in 2 20 10 humans. The 425-bp SFV integrase fragment was detected in peripheral blood DNA from 53 captive and 8 wild-caught mandrills .