tailieunhanh - Báo cáo y học: "Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques. | Xia et al. Retrovirology 2010 7 102 http content 7 1 102 RETR0VIR0L0GY RESEARCH Open Access Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques I_I II I I I V- V i 1 21 I_I z z i 7 z t 1 t I I D I z t h z 1 2 7 p z V I m I 1 2 c z z II I I 1 2 I D z I_I 1 Hou-Jun Aid Gao-Hong Zhang Jian-ring Ma Zheng-Xi Dai Shao-iou LI Jian-Bao nan Yong-Tang Zheng1 Abstract Background Several studies have demonstrated that SIV infection progresses more slowly to experimental AIDS in Chinese rhesus macaques Ch Rhs than in Indian rhesus macaques Ind Rhs . -ere we investigated the dynamic and functional changes in dendritic cell DC subsets in SIVmac239-infected Ch Rhs. Results The numbers of both mDC and pDC strongly fluctuated but were not significantly changed during the acute and chronic phases of infection. However the concentration of both poly I C -induced IL-12 and HSV-1-induced IFN-a significantly increased in the acute phase of infection but returned to normal levels at the chronic phase of infection. The peak of IFN-a emerged earlier than that of IL-12 and it had a significantly positive correlation with IL-12 which indicated that IFN-a may initiate the immune activation. We also found that only the concentration of IFN-a was positively correlated with CD4 T-cell counts but it was negatively correlated with viral load. Conclusion High levels of IFN-a in the early stage of infection may contribute to effective control of virus replication and normal levels of IFN-a during chronic infection may help Ch Rhs resist the disease progression. The change in DC subsets dynamics and cytokine production may help further our understanding of why Ch Rhs are able to live longer without progressing to an AIDS-like illness. Background Dendritic cells DC are a heterogeneous population of APC essential in linking the innate and acquired immune response 1 . Two major DC subsets CD11c myeloid DC mDC and CD123 plasmacytoid .