tailieunhanh - Báo cáo khoa học: "Fatality after deliberate ingestion of sustained-release ibuprofen: a case report"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Fatality after deliberate ingestion of sustained-release ibuprofen: a case report. | Available online http content 10 2 R44 Research Fatality after deliberate ingestion of sustained-release ibuprofen a case report David Michael Wood Jane Monaghan Peter Streete Alison Linda Jones and Paul Ivor Dargan Guy s and St Thomas Poisons Unit Guy s and St Thomas NHS Foundation Trust London UK Corresponding author David Michael Wood Received 6 Jan 2006 Revisions requested 23 Jan 2006 Revisions received 9 Feb 2006 Accepted 10 Feb 2006 Published 8 Mar 2006 Critical Care 2006 10 R44 doi cc4850 This article is online at http content 10 2 R44 2006 Wood et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Ibuprofen is a nonsteroidal anti-inflammatory drug available over the counter and on prescription for the management of pain and inflammation. Severe toxicity is rare following deliberate self-poisoning with ibuprofen and patients are usually either asymptomatic or develop only mild gastrointestinal toxicity. Although there have been nine other reported fatalities co-existent factors have probably contributed to all of these deaths. We report here a fatality from isolated toxicity following self-poisoning with sustained-release ibuprofen. Case report A 26-year-old female presented after deliberate ingestion of up to 105 g sustained-release ibuprofen with a reduced level of consciousness severe metabolic acidosis and haemodynamic compromise. Despite intensive supportive management gut decontamination with multidose activated charcoal and correction of the metabolic acidosis with sodium bicarbonate and haemofiltration the patient did not survive. The ibuprofen concentration ante mortem on presentation in peripheral blood was 760 mg l .

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