tailieunhanh - Báo cáo y học: "Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin: a case report. | Journal of Medical Case Reports BioMed Central Case report Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin a case report Adrian F Peall and Aidan Hodges Open Access Address Respiratory Department Hawke s Bay Hospital Hastings New Zealand Email Adrian F Peall - adrianpeall@ Aidan Hodges - aidan_hodges@ Corresponding author Published I August 2007 Received I March 2007 Journal of Medical Case Reports 2007 1 59 doi 1752-1947-1-59 Accepted 1 August 2007 This article is available from http content 1 1 59 2007 Peall and Hodges licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin is a rare but serious complication of the use of Nitrofurantoin. Case presentation A 72 year old woman taking Nitrofurantoin for recurrent urinary sepsis presenting with breathlessness abdominal discomfort and abnormal liver function tests is described. Drug toxicity secondary to Nitrofurantoin was diagnosed. Cessation of the drug and a course of steroids markedly improved her condition. Discussion We review the drug reactions associated with Nitrofurantoin and suggest an alternative treatment strategy for recurrent urinary sepsis. Conclusion Adverse drug reactions are an important cause of concomitant lung and liver toxicity and the mainstay of treatment is drug withdrawal. Background Nitrofurantoin is well recognized as a cause of adverse drug reactions although the combination of lung and liver toxicity is rare 1 . A case of concomitant lung and liver toxicity in a patient taking nitrofurantoin and our approach to management is described. We discuss the presentation of nitrofurantoin .