tailieunhanh - Báo cáo y học: " Journey to the heart of macrophages: the delicate relationship between HIV-1 and a multifaceted cell type"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " Journey to the heart of macrophages: the delicate relationship between HIV-1 and a multifaceted cell type. | Cimarelli Retrovirology 2010 7 28 http content 7 1 28 RETR0VIR0L0GY COMMENTARY Open Access Journey to the heart of macrophages the delicate relationship between HIV-1 and a multifaceted cell type Andrea Cimarelli1 2 3 Abstract Cells of the monocyte-macrophage lineage play multiple roles during the infection of primate lentiviruses serving as reservoirs for viral production or as vectors for viral spread to other cells and tissues. The human immunodeficiency type I virus is not only capable of establishing such complex and dynamic relations with this cell type but is also able to modulate their physiology and behavior thus shaping ensuing cellular immune responses. In this issue of Retrovirology a series of reviews explores the multiple manners in which the virus and cells belonging to the monocyte-macrophage lineage interact and affect each other. Introduction This issue of Retrovirology presents a series of reviews centered on the complex relationship established between monocytes macrophages and the human immunodeficiency type I virus HIV-1 . This cell type plays multiple and important roles during viral replication and pathogenesis serving as a haven for the multiplication of the virus as a vehicle for its spread into privileged sites as a cell type to take over and modify host immune responses. The reviews presented here deal extensively with all these issues leading the reader to appreciate the prominent role of macrophages during HIV-1 induced pathogenesis. Discussion Macrophages are resident cells that differentiate in tissues upon migration of circulating blood monocytes. Migration can occur through the blood brain barrier accounting for the passage of HIV-1 into the central nervous system or to sites of infection. Tissue residency is accompanied with the differentiation of monocytes in macrophages a differentiation that is heavily dependent on the environment in which the cells find themselves. There as professional antigen presenting