tailieunhanh - Báo cáo khoa học: "Levels of protein C and activated protein C: what do they mean"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Levels of protein C and activated protein C: what do they mean? | Available online http content 10 2 126 Commentary Levels of protein C and activated protein C what do they mean Jan A Hazelzet Erasmus MC Sophia Children s Hospital Pediatric Intensive Care Unit Rotterdam The Netherlands Corresponding author Jan A Hazelzet Published 6 March 2006 This article is online at http content 10 2 126 2006 BioMed Central Ltd Critical Care 2006 10 126 doi cc4842 See related research by Lindstrom et al. in this issue http content 10 1 R16 Abstract Acute pancreatitis is a local inflammatory process that leads to a systemic inflammatory response in the majority of cases and sometimes leads to multiple organ failure. It is obvious that coagulation and especially the protein C system are involved in this disease. The present commentary is related to a study in patients with pancreatitis with and without multiple organ failure in which protein C and activated protein C levels were studied. The protein C system and other studies analyzing activated protein C levels are discussed. Introduction In the present issue of Critical Care the Finnish group of Lindstrom and colleagues 1 describes a study in 31 patients with acute pancreatitis in which they assess the organ function and analyze the levels of protein C PC and activated protein C APC as well as the monocyte activation state in order to evaluate the turnover of PC to APC. They categorized the patients into a group n 13 with severe acute pancreatitis with multiple organ failure and a control group n 18 with severe acute pancreatitis without multiple organ failure. In the group with multiple organ failure the number of patients with decreased 70 of the adult mean levels of PC was significantly higher than in the group without multiple organ failure 92 versus 44 P . Although within normal limits in all but one patient the minimum APC level was lower in cases with multiple organ failure than in controls median versus .