tailieunhanh - Báo cáo y học: " Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques. | BioMed Central Retrovirology Research Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques Abdelkrim Mannioui1 2 Olivier Bourry1 2 Pierre Sellier1 2 3 Benoit Delache1 2 Patricia Brochard1 2 Thibault Andrieu1 2 Bruno Vaslin1 2 Ingrid Karlsson1 2 Pierre Roques1 2 and Roger Le Grand 1 2 Open Access Address 1CEA Division of Immuno-Virology DSV iMETI Fontenay-aux-Roses France 2Université Paris-Sud 11 UMR E01 Orsay France and 3Assistance Publique-Hôpitaux de Paris Service de Médecine Interne A Hôpital Lariboisière France Email Abdelkrim Mannioui - Olivier Bourry - obourry@ Pierre Sellier - Benoit Delache - Patricia Brochard - Thibault Andrieu - Bruno Vaslin - Ingrid Karlsson - IKS@ Pierre Roques - Roger Le Grand - Corresponding author Published 23 November 2009 Received 10 August 2009 Accepted 23 November 2009 Retrovirology 2009 6 106 doi 1742-4690-6-106 This article is available from http content 6 1 106 2009 Mannioui et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Extensive studies of primary infection are crucial to our understanding of the course of HIV disease. In SIV-infected macaques a model closely mimicking HIV pathogenesis we used a combination of three markers -- viral RNA 2LTR circles and viral DNA -- to evaluate viral replication and dissemination simultaneously in blood secondary lymphoid tissues and the gut during primary and chronic infections. Subsequent viral compartmentalization in the main target cells of the .