tailieunhanh - Báo cáo khoa học: "Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture. | Available online http content 9 6 R677 Open Access Research Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture Vladimir Kuklin1 Mikhail Sovershaev2 Thomas Andreasen3 Vegard Skogen4 Kirsti Ytrehus5 and Lars Bjertnaes6 Research fellow Department of Anaesthesiology Faculty of Medicine University of Tromso MH building 9037 Tromso Norway 2Research fellow Department of Physiology Faculty of Medicine University of Tromso MH building 9037 Tromso Norway departmental engineer Department of Physiology Faculty of Medicine University of Tromso MH building 9037 Tromso Norway 4Associate professor Department of Internal Medicine University Hospital of Tromso MH building 9037 Tromso Norway 5Professor Department of Physiology Faculty of Medicine University of Tromso MH building 9037 Tromso Norway 6Professor Chairman of the Department of Anaesthesiology Faculty of Medicine University of Tromso MH building 9037 Tromso Norway Corresponding author Lars Bjertnaes Received 7 Jul 2005 Revisions requested 16 Aug 2005 Revisions received 8 Sep 2005 Accepted 27 Sep 2005 Published 18 Oct 2005 Critical Care 2005 9 R677-R686 DOI 86 cc3882 This article is online at http content 9 6 R677 2005 Kuklin et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction We recently demonstrated that the non-selective endothelin-1 ET-1 receptor blocker tezosentan antagonizes ovine acute lung injury ALI following infusion of endotoxin or ET-1 by reducing the enhanced lung microvascular pressure although we could not exclude the possibility of a simultaneous decline in microvascular permeability. In the present study our