tailieunhanh - Báo cáo y học: " Human APOBEC1 cytidine deaminase edits HBV DNA Minerva Cervantes Gonzalez, Rodolphe Suspène, Michel Henry, Denise Guétard, Simon Wain-Hobson and "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " Human APOBEC1 cytidine deaminase edits HBV DNA Minerva Cervantes Gonzalez, Rodolphe Suspène, Michel Henry, Denise Guétard, Simon Wain-Hobson and. | Retrovirology BioMed Central Short report Human APOBECI cytidine deaminase edits HBV DNA Minerva Cervantes Gonzalez Rodolphe Suspène Michel Henry Denise Guétard Simon Wain-Hobson and Jean-Pierre Vartanian Open Access Address Molecular Retrovirology Unit Virology Department Institut Pasteur 28 rue du Dr Roux 75724 Paris cedex 15 France Email Minerva Cervantes Gonzalez - Rodolphe Suspène - Michel Denise Guétard - Simon Wain-Hobson - Jean-Pierre Vartanian - Corresponding author Published 21 October 2009 Retrovirology 2009 6 96 doi 1742-4690-6-96 Received 8 July 2009 Accepted 21 October 2009 This article is available from http content 6 1 96 2009 Gonzalez et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Retroviruses hepadnaviruses and some other retroelements are vulnerable to editing by single stranded DNA cytidine deaminases. Of the eleven human genes encoding such enzymes eight have demonstrable enzymatic activity. Six of seven human APOBEC3 are able to hyperedit HBV DNA frequently on both strands. Although human APOBEC1 hA1 is not generally expressed in normal liver hA1 can edit single stranded DNA in a variety of experimental assays. The possibility of ectopic expression of hA1 in vivo cannot be ruled out and interestingly transgenic mice with A1 expressed under a liver specific promoter develop hepatocellular carcinoma. The impact of hA1 on HBV in tissue culture is varied with reports noting either reduced DNA synthesis or not with cytidine deamination taking a low profile. We sought to examine the