tailieunhanh - Báo cáo y học: " An EIAV field isolate reveals much higher levels of subtype variability than currently reported for the equine lentivirus family"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " An EIAV field isolate reveals much higher levels of subtype variability than currently reported for the equine lentivirus family. | Retrovirology BioMed Central Open Access An EIAV field isolate reveals much higher levels of subtype variability than currently reported for the equine lentivirus family Jodi K Craigo1 2 Shannon Barnes1 2 Baoshan Zhang1 2 Sheila J Cook3 Laryssa Howe2 Charles J Issel3 and Ronald C Montelaro 1 2 Address 1Center for Vaccine Research University of Pittsburgh Pittsburgh PA 15261 USA 2Department of Microbiology and Molecular Genetics University of Pittsburgh Pittsburgh PA 15261 USA and 3Department of Veterinary Science University of Kentucky Lexington Kentucky 40516 USA Email Jodi K Craigo - craigoj@ Shannon Barnes - smd22@ Baoshan Zhang - baz8@ Sheila J Cook - Laryssa Howe - lhowe@ Charles J Issel - cissel@ Ronald C Montelaro - rmont@ Corresponding author Published 20 October 2009 Received 28 July 2009 Retrovirology 2009 6 95 doi 1742-4690-6-95 Accepted 20 October 2009 This article is available from http content 6 1 95 2009 Craigo et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Equine infectious anemia virus EIAV a lentivirus that infects horses has been utilized as an animal model for the study of HIV. Furthermore the disease associated with the equine lentivirus poses a significant challenge to veterinary medicine around the world. As with all lentiviruses EIAV has been shown to have a high propensity for genomic sequence and antigenic variation especially in its envelope Env proteins. Recent studies have demonstrated Env variation to be a major determinant of vaccine efficacy emphasizing the importance of defining natural variation among field isolates of EIAV. To date however published EIAV .

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