tailieunhanh - Báo cáo khoa học: "Validation of a method to partition the base deficit in meningococcal sepsis: a retrospective study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Validation of a method to partition the base deficit in meningococcal sepsis: a retrospective study. | Available online http content 9 4 R464 Research Validation of a method to partition the base deficit in meningococcal sepsis a retrospective study Ellen O Dell1 Shane M Tibby2 Andrew Durward2 Jo Aspell3 and Ian A Murdoch4 1Fellow Department of Paediatric Intensive Care Guy s and Saint Thomas Hospitals London UK 2Consultant Department of Paediatric Intensive Care Guy s and Saint Thomas Hospitals London UK 3Resident Department of Paediatric Intensive Care Guy s and Saint Thomas Hospitals London UK 4Consultant Department of Paediatric Intensive Care Guy s and Saint Thomas Hospitals London UK Corresponding author Shane M Tibby Received 26 Feb 2005 Revisions requested 14 Apr 2005 Revisions received 18 May 2005 Accepted 10 Jun 2005 Published 8 Jul 2005 Critical Care 2005 9 R464-R470 DOI 86 cc3760 This article is online at http content 9 4 R464 2005 O Dell et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The base deficit is a useful tool for quantifying total acid-base derangement but cannot differentiate between various aetiologies. The Stewart-Fencl equations for strong ions and albumin have recently been abbreviated we hypothesised that the abbreviated equations could be applied to the base deficit thus partitioning this parameter into three components the residual being the contribution from unmeasured anions . Methods The two abbreviated equations were applied retrospectively to blood gas and chemistry results in 374 samples from a cohort of 60 children with meningococcal septic shock mean pH mean base deficit meq L . Partitioning required the simultaneous measurement of plasma sodium chloride albumin and blood gas

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