tailieunhanh - Báo cáo khoa học: "Bench-to-bedside review: Antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit . | Available online http content 9 5 459 Review Bench-to-bedside review Antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit Marin H Kollef Department of Internal Medicine Pulmonary and Critical Care Division Washington University School of Medicine St Louis Missouri USA Corresponding author Marin H Kollef mkollef@ Published online 27 June 2005 This article is online at http content 9 5 459 2005 BioMed Central Ltd Critical Care 2005 9 459-464 DOI cc3757 Abstract Antimicrobial resistance has emerged as one of the most important issues complicating the management of critically ill patients with infection. This is largely due to the increasing presence of pathogenic microorganisms with resistance to existing antimicrobial agents resulting in the administration of inappropriate treatment. Effective strategies for the prevention of antimicrobial resistance within intensive care units are available and should be aggressively implemented. The importance of preventing antimicrobial resistance is magnified by the limited availability of new antimicrobial drug classes for the foreseeable future. Introduction Antimicrobial resistance has emerged as an important variable influencing patient mortality and overall resource utilization in the intensive care unit ICU setting 1-3 . ICUs worldwide are faced with increasingly rapid emergence and spread of antibiotic-resistant bacteria. Both antibiotic-resistant Gramnegative bacilli and Gram-positive bacteria are reported as important causes of hospital-acquired infections 4-12 . In many circumstances particularly with methicillin-resistant Staphylococcus aureus with vancomycin-resistant Enterococcus faecium and with Gram-negative bacteria producing extended spectrum beta-lactamases with resistance to multiple other antibiotics few antimicrobial agents remain for effective treatment 13-19 . ICUs are an important area for the .