tailieunhanh - Retrovirology Commentary BioMed Central Open Access A historical reflection on the discovery of

Retrovirology Commentary BioMed Central Open Access A historical reflection on the discovery of human retroviruses Anders Vahlne Address: Clinical Virology and Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Email: Anders Vahlne - Published: 1 May 2009 Retrovirology 2009, 6:40 doi: Received: 3 April 2009 Accepted: 1 May 2009 This article is available from: © 2009 Vahlne; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The discovery of HIV-1 as the cause of AIDS was. | Retrovirology BioMed Central Commentary A historical reflection on the discovery of human retroviruses Anders Vahlne Open Access Address Clinical Virology and Division of Clinical Microbiology Karolinska Institutet Karolinska University Hospital Stockholm Sweden Email Anders Vahlne - Published I May 2009 Received 3 April 2009 Retrovirology 2009 6 40 doi 1742-4690-6-40 Accepted 1 May 2009 This article is available from http content 6 1 40 2009 Vahlne licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The discovery of HIV-1 as the cause of AIDS was one of the major scientific achievements during the last century. Here the events leading to this discovery are reviewed with particular attention to priority and actual contributions by those involved. Since I would argue that discovering HIV was dependent on the previous discovery of the first human retrovirus HTLV-I the history of this discovery is also re-examined. The first human retroviruses HTLV-I was first reported by Robert C. Gallo and coworkers in 1980 and reconfirmed by Yorio Hinuma and coworkers in 1981. These discoveries were in turn dependent on the previous discovery by Gallo and coworkers in 1976 of interleukin 2 or T-cell growth factor as it was called then. HTLV-II was described by Gallo s group in 1982. A human retrovirus distinct from HTLV-I and HTLV-II in that it was shown to have the morphology of a lentivirus was in my mind described for the first time by Luc Montagnier in an oral presentation at Cold Spring Harbor in September of 1983. This virus was isolated from a patient with lymphadenopathy using the protocol previously described for HTLV by Gallo. The first peer reviewed paper by Montagnier s .

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