tailieunhanh - Báo cáo y học: " On the steps of cell-to-cell HIV transmission between CD4 T cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: On the steps of cell-to-cell HIV transmission between CD4 T cells. | Retrovirology BioMed Central Commentary On the steps of cell-to-cell HIV transmission between CD4 T cells Isabel Puigdomènech1 Marta Massanella1 Cecilia Cabrera1 Bonaventura Clotet1 2 and Julia Blanco 1 Open Access Address 1Fundació irsiCaixa-HIVACAT Institut de Recerca en Ciències de la Salut Germans Trias i Pujol IGTP Hospital Germans Trias Universitat Autònoma de Barcelona Badalona 08916 Barcelona Catalonia Spain and 2Lluita contra la SIDA Foundation Institut de Recerca en Ciències de la Salut Germans Trias i Pujol Hospital Universitari Germans Trias i Pujol Universitat Autònoma de Barcelona 08916 Badalona Barcelona Spain Email Isabel Puigdomènech - ipuig@ Marta Massanella - mmassanella@ Cecilia Cabrera - ccabrera@ Bonaventura Clotet-bclotet@ Julia Blanco - jblanco@ Corresponding author Published 13 October 2009 Received 31 July 2009 Retrovirology 2009 6 89 doi 1742-4690-6-89 Accepted 13 October 2009 This article is available from http content 6 1 89 2009 Puigdomènech et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Although cell-to-cell HIV transmission was defined in early 90 s in the last five years several groups have underscored the relevance of this mode of HIV spread between productively infected and uninfected CD4 T cells by defining the term virological synapse VS . However unraveling the molecular mechanisms of this efficient mode of viral spread appears to be more controversial than expected. Different authors have highlighted the role of a classical co-receptor-dependent HIV transmission while others describe a .