tailieunhanh - Retrovirology Short report BioMed Central Open Access High level expression of the

Retrovirology Short report BioMed Central Open Access High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity Eva-K Pauli1, Mirco Schmolke1, Henning Hofmann2, Christina Ehrhardt1, Egbert Flory3, Carsten Münk2 and Stephan Ludwig*1 Address: 1Institute of Molecular Virology (IMV), Centre of Molecular Biology of Inflammation (ZMBE), Westfaelische-Wilhelms-University Muenster, Münster, Germany, 2Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Duesseldorf, Germany and 3Paul-Ehrlich-Institute (PEI), Langen, Germany Email: Eva-K Pauli - evapauli@; Mirco Schmolke - ; Henning Hofmann - ; Christina Ehrhardt - ehrhardc@; Egbert Flory - floeg@; Carsten Münk - ; Stephan Ludwig* - ludwigs@ * Corresponding author Published: 16. | Retrovirology BioMed Central Open Access Short report High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity Eva-K Pauli1 Mirco Schmolke1 Henning Hofmann2 Christina Ehrhardt1 Egbert Flory3 Carsten Munk2 and Stephan Ludwig 1 Address 1Institute of Molecular Virology IMV Centre of Molecular Biology of Inflammation ZMBE Westfaelische-Wilhelms-University Muenster Munster Germany 2Clinic for Gastroenterology Hepatology and Infectiology Heinrich-Heine-University Duesseldorf Germany and 3Paul-Ehrlich-Institute PEI Langen Germany Email Eva-K Pauli - evapauli@ Mirco Schmolke - Henning Hofmann - Christina Ehrhardt - ehrhardc@ Egbert Flory - floeg@ Carsten Munk - Stephan Ludwig - ludwigs@ Corresponding author Published 16 April 2009 Received 31 October 2008 Retrovirology 2009 6 38 doi 1742-4690-6-38 Accepted 16 April 2009 This article is available from http content 6 1 38 2009 Pauli et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Human APOBEC3G is an antiretroviral protein that was described to act via deamination of retroviral cDNA. However it was suggested that APOBEC proteins might act with antiviral activity by yet other mechanisms and may also possess RNA deamination activity. As a consequence there is an ongoing debate whether APOBEC proteins might also act with antiviral activity on other RNA viruses. Influenza A viruses are single-stranded RNA viruses capable of inducing a .

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