tailieunhanh - Báo cáo khoa học: "Circulating inflammatory mediators and organ dysfunction after cardiovascular surgery with cardiopulmonary bypass: a prospective observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Circulating inflammatory mediators and organ dysfunction after cardiovascular surgery with cardiopulmonary bypass: a prospective observational study. | Available online http content 10 2 R46 Research Circulating inflammatory mediators and organ dysfunction after cardiovascular surgery with cardiopulmonary bypass a prospective observational study Hugo Tannus Furtado de Mendonga-Filho1 2 Kelly Cristina Pereira1 Mariane Fontes1 Daniel Augusto de Souza Aranha Vieira1 Maria Lucia A Furtado de Mendonọa1 Luiz Antonio de Almeida Campos1 and Hugo Caire Castro-Faria-Neto2 1Núcleo de Pesquisa Translacional Hospital Pró Cardíaco Rua General Polidoro 1 92 Botafogo Rio de Janeiro RJ 22280-000 Brazil 2Laboratório de Imunofarmacologia Departamento de Farmacodinamica Instituto Oswaldo Cruz Rio de Janeiro RJ 21 045-900 Brazil Corresponding author Hugo Tannus Furtado de Mendonọa-Filho htannus@ Received 12 Dec 2005 Revisions requested 6 Jan 2006 Revisions received 24 Jan 2006 Accepted 17 Feb 2006 Published 15 Mar 2006 Critical Care 2006 10 R46 doi cc4857 This article is online at http content 10 2 R46 2006 Mendonọa-Filho et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Cardiovascular surgery with cardiopulmonary bypass CPB has improved in past decades but inflammatory activation in this setting is still unpredictable and is associated with several postoperative complications. Perioperative levels of macrophage migration inhibitory factor MIF and other inflammatory mediators could be implicated in adverse outcomes in cardiac surgery. Methods Serum levels of MIF monocyte chemoattractant protein MCP -1 soluble CD40 ligand IL-6 and IL-10 from 93 patients subjected to CPB were measured by enzyme-linked immunosorbent assay and compared with specific and global postoperative organ dysfunctions through multiple .