tailieunhanh - Báo cáo khoa học: " Conflicting clinical trial data: a lesson from albumin"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Conflicting clinical trial data: a lesson from albumin. | Available online http content 9 6 649 Commentary Conflicting clinical trial data a lesson from albumin Greg Martin Assistant Professor of Medicine Division of Pulmonary Allergy and Critical Care Emory University School of Medicine Atlanta Georgia USA Corresponding author Greg Martin Published online 22 November 2005 This article is online at http content 9 6 649 2005 BioMed Central Ltd Critical Care 2005 9 649-650 DOI cc3931 See related research by Vincent et al. in this issue http content 9 6 R745 Abstract Albumin is a frequently prescribed drug in hospitalized patients and its effect on clinical outcomes has been scrutinized in recent years. Data from meta-analyses has suggested harm related to albumin therapy in critically ill patients and new observational data are consistent with these results. However appropriately powered randomized controlled trials have shown albumin to be safe in broad groups of critically ill patients. This article will discuss the reasons for differences between observational and controlled trial data and the implications for future albumin use and clinical research. Introduction The interpretation of clinical trial data is the cornerstone of both evidence-based medicine and medical practice 1 2 . The level of evidence that we apply to study results depends on the type of trial being reported. For example randomized controlled trials RCTs represent a higher level of evidence than observational trials. Thus RCTs more appropriately guide the practice of medicine. Observational trials are statistically and financially efficient however and almost invariably precede results from an RCT. Can we base the care of critically ill patients on the results of observational data The SOAP study The Sepsis Occurrence in Acutely Ill Patients SOAP study represents an observational trial conducted in intensive care units ICUs from 24 European countries during a two-week period. In this .

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