tailieunhanh - Báo cáo y học: " E box motifs as mediators of proviral latency of human retroviruses"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " E box motifs as mediators of proviral latency of human retroviruses. | Retrovirology BioMed Central Commentary E box motifs as mediators of proviral latency of human retroviruses Jean-Michel Terme11 Sébastien CalvignaD2 Madeleine Duc Dodon 3 Louis Gazzolo3 and Albert Jordan 1 Open Access Address 1Institut de Biologia Molecular Barcelona IBMB-CSIC Parc Cientific de Barcelona Baldiri Reixac 10 08028 Barcelona Spain 2Université de Lyon UMR CNRS 5023 Laboratoire d Ecologie des Hydrosystèmes Fluviaux Campus de la Doua 43 Boulevard du 11 novembre 1918 69622 Villeurbanne Cedex France and 3INSERM U758 Virologie Humaine IFR 128 Biosciences Lyon-Gerland Ecole Normale Supérieure de Lyon 4 Allée d Italie 69364 Lyon Cedex 07 France Email Jean-Michel Terme - Sébastien Calvignac - Madeleine Duc Dodon - Louis Albert Jordan - Corresponding authors fEqual contributors Published 16 September 2009 Received 29 April 2009 Accepted 16 September 2009 Retrovirology 2009 6 81 doi 1742-4690-6-81 This article is available from http content 6 1 81 2009 Terme et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The palindromic sequence motifs CANNTG known as E boxes are considered as binding sites for the basic helix-loop-helix bHLH class of DNA-binding proteins. Their presence has been reported in the long terminal repeats LTR of the HIV-1 and HTLV-1 proviruses. Their close proximity with the TATA region of both LTRs indicates that the bHLH proteins may act as important regulators of the function of proviral transcription. Indeed observations on .