tailieunhanh - Retrovirology Research BioMed Central Open Access A dose-effect relationship for
Retrovirology Research BioMed Central Open Access A dose-effect relationship for deltaretrovirus-dependent leukemogenesis in sheep Carole Pomier1, Maria Teresa Sanchez Alcaraz2, Christophe Debacq2, Agnes Lançon1, Pierre Kerkhofs4, Lucas Willems2, Eric Wattel†1,3 and Franck Mortreux*†1 Address: 1CNRS FRE-3011 - Université Lyon I, Oncovirologie et Biothérapies, Centre Léon Bérard, Lyon, France, 2FUSAGx, Molecular and cellular biology, Gembloux, Belgium, 3Hôpital Edouard Herriot, Service d'Hématologie, Pavillon E, Lyon, France and 4Veterinary and Agrochemical Research Centre, Department of Virology, Uccle, Belgium Email: Carole Pomier - ptepoms@; Maria Teresa Sanchez Alcaraz - mteresasanchez@; Christophe Debacq - ; Agnes Lançon - lancon@; Pierre Kerkhofs - piker@; Lucas Willems - ; Eric Wattel - wattel@;. | Retrovirology BioMed Central Research A dose-effect relationship for deltaretrovirus-dependent leukemogenesis in sheep Carole Pomier1 Maria Teresa Sanchez Alcaraz2 Christophe Debacq2 Agnes Lanẹon1 Pierre Kerkhofs4 Lucas Willems2 Eric Wattel41 3 and Franck Mortreux 41 Open Access Address 1CNRS FRE-3011 - Université Lyon I Oncovirologie et Biothérapies Centre Léon Bérard Lyon France 2FUSAGx Molecular and cellular biology Gembloux Belgium 3Hôpital Edouard Herriot Service d Hématologie Pavillon E Lyon France and Veterinary and Agrochemical Research Centre Department of Virology Uccle Belgium Email Carole Pomier - ptepoms@ Maria Teresa Sanchez Alcaraz - mteresasanchez@ Christophe Debacq - Agnes Lanẹon - lancon@ Pierre Kerkhofs - piker@ Lucas Willems - Eric Wattel - wattel@ Franck Mortreux - mortreux@ Corresponding author tEqual contributors Published 3 April 2009 Received 12 November 2008 Retrovirology 2009 6 30 doi 1742-4690-6-30 Accepted 3 April 2009 This article is available from http content 6 1 30 2009 Pomier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Retrovirus-induced tumors develop in a broad range of frequencies and after extremely variable periods of time from only a few days to several decades depending mainly on virus type. For hitherto unexplained reasons deltaretroviruses cause hematological malignancies only in a minority of naturally infected organisms and after a very prolonged period of clinical latency. Results Here we demonstrate that the development of malignancies in sheep experimentally infected with the deltaretrovirus .
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