tailieunhanh - Báo cáo khoa học: "Time course of endothelial damage in septic shock: prediction of outcome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Time course of endothelial damage in septic shock: prediction of outcome. | Available online http content 9 4 R323 Research Time course of endothelial damage in septic shock prediction of outcome Ortrud Vargas Hein Klaudia Misterek Jan-Peer Tessmann Vera van Dossow Michael Krimphove and Claudia Spies Department of Anesthesiology and Intensive Care University Hospital Charité Campus Mitte Berlin Germany Corresponding author Claudia Spies Received 7 Nov 2004 Revisions requested 9 Jan 2005 Revisions received 29 Mar 2005 Accepted 7 Apr 2005 Published 13 May 2005 Critical Care 2005 9 R323-R330 DOI 86 cc3532 This article is online at http content 9 4 R323 2005 Vargas Hein et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract Introduction Endothelial damage accounts greatly for the high mortality in septic shock. Higher expression of mediators IL-6 IL-8 soluble intercellular adhesion molecule 1 sICAM-1 soluble endothelial-linked adhesion molecule 1 sELAM-1 have been described for non-survivors in comparison with survivors. We investigated the predictive value of the mediators IL-6 IL-8 sELAM-1 and sICAM-1 and their time course in intensive care unit patients who developed septic shock with respect to outcome. Materials and methods We measured serum levels of IL-6 IL-8 sELAM-1 and sICAM-1 in 40 intensive care unit patients who developed septic shock. Measurements were performed until death or until resolution of septic shock. Clinical and laboratory data were also recorded. Results After 48 hours the levels of sELAM-1 and sICAM-1 increased in non-survivors and decreased in survivors. sELAM- 1 was predictive for outcome on the third day P and the fourth day P after diagnosis of septic shock. This difference in the time course .