tailieunhanh - Báo cáo khoa học: " Narcotic-based sedation regimens for critically ill mechanically ventilated patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Narcotic-based sedation regimens for critically ill mechanically ventilated patients. | Available online http content 9 3 247 Commentary Narcotic-based sedation regimens for critically ill mechanically ventilated patients Pratik Pandharipande1 and E Wesley Ely2 Assistant Professor Department of Anesthesiology Division of Critical Care Vanderbilt University School of Medicine Nashville Tennessee USA 2Associate Professor Department of Medicine Center for Health Services Research and Division of Allergy Pulmonary Critical Care Medicine Vanderbilt University School of Medicine and the VA Tennessee Valley Geriatric Research Education and Clinical Center GRECC Nashville Tennessee USA Corresponding author Pratik Pandharipande Published online 18 April 2005 This article is online at http content 9 3 247 2005 BioMed Central Ltd Critical Care 2005 9 247-248 DOI cc3523 See related research by Breen et al. in this issue http content 9 3 R200 Abstract Sedatives and analgesics are routinely used in the intensive care unit to relieve pain and anxiety. These agents have numerous side effects and may contribute to poor outcomes such as increased length of mechanical ventilation longer ICU stays and acute and long-term cognitive dysfunction. Modifying sedation paradigms utilizing either narcotic-based regimens with remifentanil or fentanyl or by using a2 agonists such as dexmedetomidine may help in improving these outcomes in critically ill patients. Benzodiazepines and narcotics are an integral component of the pharmacological treatment of millions of critically ill mechanically ventilated patients. This month in Critical Care Breen and coworkers 1 report that narcotic-based sedation strategies compared with the traditional approach involving benzodiazepines with supplemental analgesics for pain might have improved patient outcomes. In this prospective randomized unblinded trial target-based sedation with remifentanil and rescue midazolam was associated with decreased duration of .