tailieunhanh - Báo cáo khoa học: "Adhesion of the probiotic bacterium Lactobacillus plantarum 299v onto the gut mucosa in critically ill patients: a randomised open trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Adhesion of the probiotic bacterium Lactobacillus plantarum 299v onto the gut mucosa in critically ill patients: a randomised open trial | Available online http content 9 3 R285 Research Adhesion of the probiotic bacterium Lactobacillus plantarum 299v onto the gut mucosa in critically ill patients a randomised open trial Bengt Klarin1 Marie-Louise Johansson2 Goran Molin3 Anders Larsson4 and Bengt Jeppsson5 Open Access Consultant Assistant Professor Department of Anaesthesiology Intensive Care University Hospital Lund Sweden 2Research manager Probi AB Ideon Lund Sweden 3Professor Laboratory of Food Hygiene Lund University Lund Sweden 4Professor Department of Anaesthesiology Aalborg University Hospital Aalborg Denmark 5Professor Department of Surgery University Hospital Malmo Sweden Corresponding author Bengt Klarin Received 22 Nov 2004 Revisions requested 9 Feb 2005 Revisions received 3 Mar 2005 Accepted 18 Mar 2005 Published 28 Apr 2005 Critical Care 2005 9 R285-R293 DOI 86 cc3522 This article is online at http content 9 3 R285 2005 Klarin et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract Introduction To achieve any possible positive effect on the intestinal mucosa cells it is important that probiotics adhere tightly onto the intestinal mucosa. It has been shown in healthy volunteers that Lactobacillus plantarum 299v Lp 299v DSM 9843 a probiotic bacterium given orally in a fermented oatmeal formula adheres onto the intestinal mucosa but whether this also occurs in critically ill patients is unknown. Methods After randomisation nine enterally fed critically ill patients treated with broad-spectrum antibiotics received an oatmeal formula fermented with Lp 299v throughout their stay in the intensive care unit eight patients served as controls. Biopsies of the rectal mucosa were made at admission and then .