tailieunhanh - Retrovirology Research BioMed Central Open Access In vivo expression of the HBZ gene of HTLV-1
Retrovirology Research BioMed Central Open Access In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) Mineki Saito*1,4, Toshio Matsuzaki2, Yorifumi Satou3, Jun-ichirou Yasunaga3, Kousuke Saito1, Kimiyoshi Arimura2, Masao Matsuoka3 and Yoshiro Ohara1 Address: 1Department of Microbiology, Kanazawa Medical University, Ishikawa 920-0293, Japan, 2Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, 3Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan and 4Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan Email: Mineki Saito*. | Retrovirology BioMed Central Open Access In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load inflammatory markers and disease severity in HTLV-1 associated myelopathy tropical spastic paraparesis HAM TSP Mineki Saito 1 4 Toshio Matsuzaki2 Yorifumi Satou3 Jun-ichirou Yasunaga3 Kousuke Saito1 Kimiyoshi Arimura2 Masao Matsuoka3 and Yoshiro Ohara1 Address Department of Microbiology Kanazawa Medical University Ishikawa 920-0293 Japan 2Department of Neurology and Geriatrics Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima 890-8520 Japan Laboratory of Virus Immunology Institute for Virus Research Kyoto University Kyoto 606-8507 Japan and 4Department of Immunology Graduate School of Medicine University of the Ryukyus Okinawa 903-0215 Japan Email Mineki Saito - mineki@ Toshio Matsuzaki - zaki7@ Yorifumi Satou - ysatou@ Jun-ichirou Yasunaga - jyasunag@ Kousuke Saito - kousukes@ Kimiyoshi Arimura - ari@ Masao Matsuoka - mmatsuok@ Yoshiro Ohara - ohara@ Corresponding author Published 19 February 2009 Received 27 November 2008 Retrovirology 2009 6 19 doi 1742-4690-6-19 Accepted 19 February 2009 This article is available from http content 6 1 19 2009 Saito et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recently human T-cell leukemia virus type 1 HTLV-1 basic leucine zipper factor HBZ encoded from a minus strand mRNA was discovered and was suggested to play an important role in adult T cell leukemia ATL development. However there have been no reports on the role of HBZ in .
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