tailieunhanh - Retrovirology Research BioMed Central Open Access HIV-1 TAR miRNA protects against apoptosis by
Retrovirology Research BioMed Central Open Access HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression Zachary Klase1, Rafael Winograd1, Jeremiah Davis1, Lawrence Carpio1, Richard Hildreth1, Mohammad Heydarian2, Sidney Fu2, Timothy McCaffrey2, Eti Meiri3, Mila Ayash-Rashkovsky3, Shlomit Gilad3, Zwi Bentwich3 and Fatah Kashanchi*1 Address: 1The Department of Microbiology, Immunology and Tropical Medicine program, The George Washington University School of Medicine, Washington, District of Columbia 20037, USA, 2The Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington, District of Columbia 20037, USA and 3Rosetta Genomics Ltd., Rehovot, Israel Email: Zachary Klase - bcmzak@; Rafael Winograd - rafi86@; Jeremiah Davis - jeremiahmd@;. | Retrovirology BioMed Central Research HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression Zachary Klase1 Rafael Winograd1 Jeremiah Davis1 Lawrence Carpio1 Richard Hildreth1 Mohammad Heydarian2 Sidney Fu2 Timothy McCaffrey2 Eti Meiri3 Mila Ayash-Rashkovsky3 Shlomit Gilad3 Zwi Bentwich3 and Fatah Kashanchi 1 Address rfhe Department of Microbiology Immunology and Tropical Medicine program The George Washington University School of Medicine Washington District of Columbia 20037 USA 2The Department of Biochemistry and Molecular Biology The George Washington University School of Medicine Washington District of Columbia 20037 USA and 3Rosetta Genomics Ltd. Rehovot Israel Email Zachary Klase - bcmzak@ Rafael Winograd - rafi86@ Jeremiah Davis - jeremiahmd@ Lawrence Carpio - carpioll84@ Richard Hildreth - rl_hildreth@ Mohammad Heydarian - mh56@ Sidney Fu - bcmsxf@ Timothy McCaffrey - mcc@ Eti Meiri - emeiri@ Mila Ayash-Rashkovsky-mayash@ Shlomit Gilad - sgilad@ Zwi Bentwich - zbentwich@ Fatah Kashanchi - bcmfxk@ Corresponding author Open Access Published 16 February 2009 Received 15 August 2008 Retrovirology 2009 6 18 doi 1742-4690-6-18 Accepted 16 February 2009 This article is available from http content 6 1 18 2009 Klase et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background RNA interference is a gene regulatory mechanism that employs small RNA molecules such as microRNA. Previous work has shown that HIV-1 produces TAR .
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