tailieunhanh - Báo cáo khoa học: "Hydrocortisone infusion may improve survival in patients with severe community-acquired pneumonia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hydrocortisone infusion may improve survival in patients with severe community-acquired pneumonia. | Available online at http content 9 6 E24 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique Hydrocortisone infusion may improve survival in patients with severe community-acquired pneumonia Murugan Raghavan1 and John A. Kellum2 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Associate Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 20 October 2005 This article is online at http 9 6 E24 2005 BioMed Central Ltd Critical Care 9 E24 DOI 10 1186 cc3896 Expanded Abstract Citation Confalonieri M Urbino R Potena A Piattella M Parigi P Puccio G Della PR Giorgio C Blasi F Umberger R Meduri GU Hydrocortisone infusion for severe community-acquired pneumonia a preliminary randomized study. Am J Respir Crit Care Med 2005 171 242-248 1 . Hypothesis Hydrocortisone infusion in severe community-acquired pneumonia CAP attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications. Methods Design Prospective randomized double-blind placebo-controlled multi-center clinical trial. Setting Intensive care units and respiratory intermediate units of six hospitals in Italy between July 2000 and March 2003. Subjects Forty-six patients admitted to the intensive care unit with clinical and radiographic evidence of pneumonia and either two minor or one major 1993 American Thoracic Society criterion for severe pneumonia. Patients with nosocomial pneumonia immunosuppression acute burn injury pregnancy life expectancy less than 3 months and conditions requiring more than mg kg day of prednisone equivalent such as acute asthma and COPD were excluded. Intervention Subjects were randomly assigned to receive .