tailieunhanh - Báo cáo khoa học: "Acute pancreatitis: a possible role for activated protein"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Acute pancreatitis: a possible role for activated protein C? | Available online http content 9 3 243 Commentary Acute pancreatitis a possible role for activated protein C Linda Kirschenbaum and Mark Astiz Saint Vincents Hospital New York New York USA Corresponding author Mark E Astiz meastiz@ Published online 13 April 2005 Critical Care 2005 9 243-244 DOI cc3515 This article is online at http content 9 3 243 2005 BioMed Central Ltd See related research by Yamanel et al. in this issue http content 9 3 R184 Abstract Acute pancreatitis results from a sequence of events that involve the systemic inflammatory response. Activated C has multiple antiinflammatory activities and may attenuate the degree of pancreatic injury and systemic organ dysfunction when infused early in pancreatitis Acute pancreatitis results from a sequence of pathologic events that involves the systemic inflammatory response 1 2 . The initial event is activation and retention of digestive enzymes in the acinar cells with subsequent cellular injury. In addition the acinar cells release inflammatory mediators which leads to recruitment of neutrophils formation of free radicals and activation of the complement system. The neutrophils and macrophages generate additional cytokines nitric oxide platelet-activating factor PAF and other substances. The amplified inflammatory response exacerbates the pancreatic injury causing evolution from an edematous to a necrotic pancreas. Spillage of the inflammatory mediators into the systemic circulation produces organ failure. The importance of the inflammatory cascade in this process is evidenced by the correlation of serum IL-6 with disease severity in acute pancreatitis 3 . Multiple experimental studies have examined the role of therapies directed at modulating the inflammatory response in acute pancreatitis. The hypothesis is that interventions applied early in the course of pancreatitis can attenuate the severity of pancreatic injury and the associated systemic organ .

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