tailieunhanh - Báo cáo khoa học: " Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate. | Critical Care December 2005 Vol 9 No 6 Reade and Fink Review Bench-to-bedside review Amelioration of acute renal impairment using ethyl pyruvate Michael C Reade1 and Mitchell P Fink2 1Senior Registrar in Intensive Care Medicine Austin Hospital University of Melbourne Heidelberg Melbourne Victoria Australia 2Professor and Chair Department of Critical Care Medicine Watson Professor of Surgery University of Pittsburgh Pittsburgh Pennsylvania USA Corresponding author M Reade mreade@ Published online 21 October 2005 This article is online at http content 9 6 556 2005 BioMed Central Ltd Critical Care 2005 9 556-560 DOI cc3892 Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with beneficial effects in animal models of oxidative stress. Because sodium pyruvate rapidly degrades in solution a simple derivative of pyruvic acid namely ethyl pyruvate has been investigated as a therapeutic agent in preclinical studies. Ethyl pyruvate reduces organ system damage in ischaemia reperfusion injury and haemorrhagic and endotoxic shock at least in part through its antioxidant action. In addition ethyl pyruvate appears to have direct beneficial effects on cytokine expression and proinflammatory gene regulation. The effect is long lasting and importantly even when it is administered after the onset of inflammation it can ameliorate organ damage and improve survival. Ethyl pyruvate is a widely used as a food additive and was shown to be safe in phase I clinical trials. We suggest ethyl pyruvate warrants further evaluation in the management of acute renal impairment. Introduction Acute renal failure is associated with oxidative stress 1 . This relationship appears to be both cause and effect because dialysis reduces .