tailieunhanh - Báo cáo khoa học: "Human endotoxemia and human sepsis: limits to the mode"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Human endotoxemia and human sepsis: limits to the model. | Available online http content 9 2 151 Commentary Human endotoxemia and human sepsis limits to the model Ramon Anel1 and Anand Kumar2 Assistant Professor Section of Critical Care Medicine Section of Nephrology University of North Dakota Grand Forks North Dakota USA 2Associate Professor Section of Critical Care Medicine Section of Infectious Diseases University of Manitoba Winnipeg Canada and University of Medicine and Dentistry UMDNJ Camden New Jersey USA Corresponding author Anand Kumar akumar61@ Published online 4 March 2005 This article is online at http content 9 2 151 2005 BioMed Central Ltd Critical Care 2005 9 151-152 DOI cc3501 See related research by van Eijk et al. in this issue http content 9 2 R157 Abstract Sepsis remains the most common cause of death in intensive care units of the developed world. Accurate models of this disease syndrome are crucial for to the understanding of the complex pathophysiology of this disorder. The administration of a small dose of lipopolysaccharide to healthy volunteers is one such model of spontaneous human sepsis. Although this human endotoxemia model appears to be reasonably effective in mimicking early biochemical metabolic hematologic and cardiovascular septic responses in septic shock the ability to mimic other aspects of human sepsis is open to question. The current study demonstrates that human experimental endotoxemia fails to generate evidence of increased vascular permeability within the relatively short time frame of the study. Sepsis continues to be the most common cause of death in nonsurgical intensive care units. The mortality rate has remained high and substantially unchanged over the past century 1 . Recently there has been a flurry of investigative work demonstrating the clinical benefit of certain interventions for sepsis severe sepsis and septic shock 2 . The studies documenting improved outcomes with these therapies were borne of earlier efforts to