tailieunhanh - Báo cáo khoa học: "Corticosteroids increased short and long-term mortality in adults with traumatic head injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Corticosteroids increased short and long-term mortality in adults with traumatic head injury. | Available online at http content 9 5 E21 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique Corticosteroids increased short and long-term mortality in adults with traumatic head injury Michael S. Czekajlo1 and Eric B. Milbrandt2 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Assistant Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 8 September 2005 This article is online at http content 9 5 E21 2005 BioMed Central Ltd Critical Care 9 E21 DOI cc3813 Expanded Abstract Citation Roberts I Yates D Sandercock P Farrell B Wasserberg J Lomas G Cottingham R Svoboda P Brayley N Mazairac G Laloe V Munoz-Sanchez A Arango M Hartzenberg B Khamis H Yutthakasemsunt S Komolafe E Olldashi F Yadav Y Murillo-Cabezas F Shakur H Edwards P Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury MRC CRASH trial randomised placebo-controlled trial. Lancet 2004 364 1321-1328 1 . Background Corticosteroids have been used to treat head injuries for more than 30 years. In 1997 findings of a systematic review suggested that these drugs reduce risk of death by 1-2 . The CRASH trial a multicentre international collaboration aimed to confirm or refute such an effect by recruiting 20 000 patients. In May 2004 the data monitoring committee disclosed the unmasked results to the steering committee which stopped recruitment. Methods 10 008 adults with head injury and a Glasgow coma score GCS of 14 or less within 8 hours of injury were randomly allocated 48 hour infusion of corticosteroids methylprednisolone or placebo. Primary outcomes were death within 2-weeks of injury and death or disability at 6months. Prespecified