tailieunhanh - The Science and Technology Behind the Human Genome Project

This book is an outgrowth of the George Fisher Baker Lecture series presented by one of us (.) at Cornell University in the fall of 1992. This author is tremendously grateful to all those at Cornell who made this occasion truly memorable, personally, and most pro- ductive, intellectually. Included especially are Jean Fréchet, Barbara Baird, John Clardy, Jerrold Meinwald, Fred McLafferty, Benjamin Widom, David Usher, and Quentin Gibson, among many others. He also wants to express great thanks to Rick Bourke, who, several times provided extraordinary help, without which lectures would have been missed or required rescheduling | GENOMICS The Science and Technology Behind the Human Genome Project Charles R. Cantor Cassandra L. Smith Center for Advanced Biotechnology Boston University Boston Massachusetts A Wiley-Interscience Publication JOHN WILEY SONS INC. New York Chichester Weinheim Brisbane Singapore Toronto Designations used by companies to distinguish their products are often claimed as trademarks. In all instances where John Wiley Sons Inc. is aware of a claim the product names appear in initial capital or ALL CAPITAL LETTERS. Readers however should contact the appropriate companies for more complete information regarding trademarks and registration. c-syri-at 1999 by JohnWiley Sons 1ne. All rightsreserved. IT 9 . . 9 9 . in pertor thin hubheatiosmayr hrerroduced stored ina retrievalsystem ortrmisvuttedmanyfoni-s rby ttoymcaeh eTscintriormnhanican Jtthudiyguptcahtog downloedmg hrinttygi dne9mpilin9 renor9ing or elherwiso except as permitted under Sections 107 or 108 of the 1976 United States Copyright Act without the prior written permission of the Publicapt. Requeues to thePuUTi-hr fotpermlssinn cid u9i 9eed9sessed to the Permissions Department John Wiley Sons Inc. 605 Third Avenue NtwYork NY toirj lb- 850-6911 fax 2S2 8r0-609di OcMntt PEI9MREQ@. . . . . . . tlN- 9 - 18 968 to jptsmide Jr oteilq anOaqthotiPatime inRormation to recacato Al subject mattercccined. -t it cL 19 6Q tie uober9 ee lml O9lllll6 publiiher tsnptecmahai torehOorinbprofes-to991 rendc-chlf ptyfe slcnal advictht othe-exreetassithmce 5 rNPsmdQo N-nicetof aeompeth9tprofessio9alpereoq should besoughe. d-M-i lara ISBN 0-471-22056-6 nhi9 till. ii alt avsdebleto prtoCdsISniN0-49l-5990at6. Oyr I 9 rt information abou Whey ytt c - dr it our web pitc to elpr .-9 liPcC6i . Dedicated to Charles DeLisi who started it. Rick Bourke who made it so much fun to explain .