tailieunhanh - Báo cáo hóa học: " Diagnostic evaluation of three cardiac software packages using a consecutive group of patients"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Diagnostic evaluation of three cardiac software packages using a consecutive group of patients | Johansson et al. EJNMMI Research 2011 1 22 http content 1 1 22 9 EJNMMI Research a SpringerOpen Journal ORIGINAL RESEARCH Open Access Diagnostic evaluation of three cardiac software packages using a consecutive group of patients 1 1 2 2 - I- - 2 124 Lena Johansson Milan Lomsky Jens Marving Mattias Ohlsson Sven-Eric Svensson and Lars Edenbrandt Abstract Purpose The aim of this study was to compare the diagnostic performance of the three software packages 4DMSPECT 4DM Emory Cardiac Toolbox ECTb and Cedars Quantitative Perfusion SPECT QPS for quantification of myocardial perfusion scintigram MPS using a large group of consecutive patients. Methods We studied 1 052 consecutive patients who underwent 2-day stress rest 99mTc-sestamibi MPS studies. The reference gold-standard classifications for the MPS studies were obtained from three physicians with more than 25 years each of experience in nuclear cardiology who re-evaluated all MPS images. Automatic processing was carried out using 4DM ECTb and QPS software packages. Total stress defect extent TDE and summed stress score SSS based on a 17-segment model were obtained from the software packages. Receiver-operating characteristic ROC analysis was performed. Results A total of 734 patients were classified as normal and the remaining 318 were classified as having infarction and or ischemia. The performance of the software packages calculated as the area under the SSS ROC curve were for 4DM for QPS and for ECTb QPS vs. ECTb p other differences p . The area under the TDE ROC curve were for 4DM for QPS and for ECTb QPS vs. ECTb p other differences p . Conclusion There are considerable differences in performance between the three software packages with 4DM showing the best performance and ECTb the worst. These differences in performance should be taken in consideration when software packages are used in clinical routine or in clinical studies. Keywords .