tailieunhanh - Báo cáo y học: "Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury. | Journal of Inflammation BioMed Central Research Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury Jennifer L Strande 1 Kasi V Routhu1 Anna Hsu2 Alfred C Nicolosi3 and John E Baker3 4 Open Access Address 1Division of Cardiovascular Medicine Medical College of Wisconsin Milwaukee Wisconsin USA 2Department of Pharmacology and Toxicology Medical College of Wisconsin Milwaukee Wisconsin USA 3Division of Cardiothoracic Surgery Medical College of Wisconsin Milwaukee Wisconsin USA and 4Department of Pharmacology and Toxicology Medical College of Wisconsin Milwaukee Wisconsin USA Email Jennifer L Strande - jstrande@ Kasi V Routhu - krouthu@ Anna Hsu - ahsu@ Alfred C Nicolosi - anicolos@ John E Baker - jbaker@ Corresponding author Published 10 December 2009 Received 3 August 2009 Accepted 10 December 2009 Journal of Inflammation 2009 6 34 doi l476-9255-6-34 This article is available from http content 6 1 34 2009 Strande et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The lanthanide cation gadolinium GdCl3 protects the myocardium against infarction following ischemia and reperfusion. Neutrophils and macrophages are the main leukocytes responsible for infarct expansion after reperfusion. GdCl3 interferes with macrophage and neutrophil function in the liver by decreasing macrophage secretion of inflammatory cytokines and neutrophil infiltration. We hypothesized that GdCl3 protects against ischemia and reperfusion injury by decreasing inflammation. We determined the impact of GdCl3 treatment for reperfusion injury on 1 circulating monoctye and neutrophil counts 2 secretion of inflammatory cytokines and 3