tailieunhanh - Báo cáo hóa học: " One-step fabrication of biocompatible chitosancoated ZnS and ZnS:Mn2+ quantum dots via a gradiation route"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : One-step fabrication of biocompatible chitosancoated ZnS and ZnS:Mn2+ quantum dots via a gradiation route | Chang et al. Nanoscale Research Letters 2011 6 591 http content 6 1 591 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access One-step fabrication of biocompatible chitosan-coated ZnS and ZnS Mn2 quantum dots via a g-radiation route Shu-quan Chang Bin Kang Yao-dong Dai Hong-xu Zhang and Da Chen Abstract Biocompatible chitosan-coated ZnS quantum dots CS-ZnS QDs and chitosan-coated ZnS Mn2 quantum dots CS-ZnS Mn2 QDs were successfully fabricated via a convenient one-step g-radiation route. The as-obtained QDs were around 5 nm in diameter with excellent water-solubility. These QDs emitting strong visible blue or orange light under UV excitation were successfully used as labels for PANC-1 cells. The cell experiments revealed that CS-ZnS and CS-ZnS Mn2 QDs showed low cytotoxicity and good biocompatibility which offered possibilities for further biomedical applications. Moreover this convenient synthesis strategy could be extended to fabricate other nanoparticles coated with chitosan. PACS . Keywords quantum dots Y-radiation chitosan ZnS ZnS Mn2 biocompatible Introduction Recently quantum dots QDs have shown great potential in biomedical applications 1-3 . How to minimize the cytotoxicity of QDs is still a great challenge for their clinical applications 4-6 . In the past few years great efforts have been paid to reduce the toxicity of QDs. Various coatings such as ZnS shell thiol-containing molecules PEG and other polymers have been developed to modify the QDs to reduce their cytotoxicity 7-10 . Moreover a series of non-heavy-metal QDs such as InGaP ZnS ZnS and ZnS Mn2 have also been investigated to solve the toxicity problem 11-13 . Significant progresses have been made in producing high quality ZnS and ZnS Mn2 QDs by wet chemical methods 14-18 . However most of these synthesis strategies require the use of an environmentally hazardous organic solvent or surfactant which is not .