tailieunhanh - Báo cáo y học: "Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines. | Journal of Inflammation BioMed Central Research Terameprocol a methylated derivative of nordihydroguaiaretic acid inhibits production of prostaglandins and several key inflammatory cytokines and chemokines D Eads RL Hansen AO Oyegunwa CE Cecil CA Culver F Scholle ITD Petty and SM Laster Open Access Address Department of Microbiology North Carolina State University Raleigh NC 27695 USA Email D Eads - dawn_eads@ RL Hansen - rebecca_hansen@ AO Oyegunwa - CE Cecil - chad_cecil@ CA Culver - cariculver@ F Scholle - frank_scholle@ ITD Petty - tim_petty@ SM Laster - scott_laster@ Corresponding author Published 8 January 2009 Received 30 July 2008 Accepted 8 January 2009 Journal of Inflammation 2009 6 2 doi 186 1476-9255-6-2 This article is available from http content 6 1 2 2009 Eads et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Extracts of the creosote bush Larrea tridentata have been used for centuries by natives of western American and Mexican deserts to treat a variety of infectious diseases and inflammatory disorders. The beneficial activity of this plant has been linked to the compound nordihydroguaiaretic acid NDGA and its various substituted derivatives. Recently tetra-O-methyl NDGA or terameprocol TMP has been shown to inhibit the growth of certain tumor-derived cell lines and is now in clinical trials for the treatment of human cancer. In this report we ask whether TMP also displays anti-inflammatory activity. TMP was tested for its ability to inhibit the LPS-induced production of inflammatory lipids and cytokines in vitro. We also examined the effects of TMP on production of TNF-a