tailieunhanh - Báo cáo y học: "Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of . | Journal of Inflammation BioMed Central Research Polyphenol-rich pomegranate fruit extract POMx suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-kB in human KU812 cells Zafar Rasheed1 Nahid Akhtar1 Arivarasu N Anbazhagan1 Sangeetha Ramamurthy1 Meenakshi Shukla2 and Tariq M Haqqi 1 Address Department of Pathology Microbiology Immunology School of Medicine University of South Carolina 6439 Garners Ferry Road Columbia SC-29209 USA and 2Department of Medicine Division of Rheumatology Case Western Reserve University Cleveland OH-44106 USA Email Zafar Rasheed - zafarasheed@ Nahid Akhtar - nakhtar@ Arivarasu N Anbazhagan - arivarasu@ Sangeetha Ramamurthy-sramamurthy@ Meenakshi Shukla - Tariq M Haqqi - Corresponding author Open Access Published 8 January 2009 Received 12 September 2008 Journal of Inflammation 2009 6 1 doi 186 1476-9255-6-1 Accepted 8 January 2009 This article is available from http content 6 1 1 2009 Rasheed et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Mast cells and basophils are multifunctional effector cells and contain plentiful secretary granules in their cytoplasm. These cell types are involved in several inflammatory and immune events and are known to produce an array of mediators including a broad spectrum of cytokines. Pomegranate fruit is rich in anthocyanins and hydrolysable tannins a group of polyphenolic compounds shown to be potent antioxidant with anti-inflammatory activity. However no studies have been undertaken to investigate whether a polyphenol-rich pomegranate .