tailieunhanh - Báo cáo y học: "CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway. | Journal of Inflammation o BioMed Central CCR5 signalling but not DARC or D6 regulatory chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway Julie Catusse David J Clark and Ursula A Gompels Address Pathogen Molecular Biology Unit Department of Infectious Tropical Diseases London School of Hygiene Tropical Medicine University of London Keppel St London WC1E 7HT UK Email Julie Catusse - jcatusse@ David J Clark - dclark@ Ursula A Gompels - Corresponding author Published 30 July 2009 Journal of Inflammation 2009 6 22 doi 1476-9255-6-22 Received 24 March 2009 Accepted 30 July 2009 This article is available from http content 6 1 22 2009 Catusse et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Herpesviruses have evolved chemokines and chemokine receptors which modulate the recruitment of human leukocytes during the inflammatory response to infection. Early postinfection human herpesvirus 6A HHV-6A infected cells express the chemokine receptor U51A and chemokine U83A which have complementary effects in subverting the CC-chemokine family thereby controlling anti-viral leukocyte recruitment. Here we show that to potentiate this activity the viral chemokine can also avoid clearance by scavenger chemokine receptors DARC and D6 which normally regulate an inflammatory response. Conversely U83A delays internalisation of its signalling target receptor CCR5 with diversion to caveolin rich membrane domains. This mechanism can redirect displaced human chemokines to DARC and D6 for clearance of the antiviral inflammatory response leaving the .