tailieunhanh - Báo cáo y học: " Is inflammation a consequence of extracellular hyperosmolarity"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Is inflammation a consequence of extracellular hyperosmolarity? | Journal of Inflammation BioMed Central Research Is inflammation a consequence of extracellular hyperosmolarity Laurent Schwartz 1 Adeline Guais2 Mohammad Pooya3 and Mohammad Abolhassani3 Address Service de Radiothérapie Hôpital Pitié-Salpétrière Paris 75013 France 2Biorébus Paris 75008 France and 3Pasteur Institute of Iran BCG Department Tehran 13164 Iran Email Schwartz Laurent - Guais Adeline - Pooya Mohammad - m_pooya@ Abolhassani Mohammad - mabolhas@ Corresponding author Open Access Published 23 June 2009 Received 13 January 2009 Journal of Inflammation 2009 6 21 doi l476-9255-6-2l Accepted 23 June 2009 This article is available from http content 6 l 2l 2009 Schwartz et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background There are several reports suggesting that hyperosmolarity induces inflammation. We recently showed that Dextran Sodium Sulfate causes inflammatory bowel disease due to hyperosmolarity. The aim of this study was to confirm the link between hyperosmolarity and inflammation by assessing osmolarity values in vivo during inflammation compare the inflammatory potential of different osmotic agents and finally study the long-term consequences of hyperosmolarity on cell fate. Methods Osmotic pressures were measured in inflammatory liquids withdrawn from mice subjected to inflammation caused either by subcutaneous injection of Bacille Calmette-Guérin BCG or Freund adjuvant. Three epithelial cell lines HT29 T24 and A549 were exposed up to 48 hours to increasing osmolarities 300 600 900 mOsm of chemically inert molecules such as Mannitol Propylene Glycol and Glycerol and

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