tailieunhanh - Báo cáo y học: "Proanthocyanidins, from Ribes nigrum leaves, reduce"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Proanthocyanidins, from Ribes nigrum leaves, reduce . | Journal of Inflammation BioMed Central Research Open Access Proanthocyanidins from Ribes nigrum leaves reduce endothelial adhesion molecules ICAM-1 and VCAM-1 N Garbacki 1 M Kinet1 B Nusgens2 D Desmecht3 and J Damas1 Address 1Laboratoire de Physiologie humaine CHU Tour 3 Université de Liège Avenue de l Hopital 3 B-4000 Sart Tilman Belgium 2Laboratoire de Biologie des Tissus Conjonctifs Tour 3 Université de Liège Avenue de l Hopital 3 B-4000 Sart Tilman Belgium and 3Département de Morphologie et de Pathologie Pathologie générale Faculté de Médecine vétérinaire Université de Liège bvd de Colonster 20 B-4000 Sart Tilman Belgium Email N Garbacki - M Kinet - kinet_marie@ B Nusgens - D Desmecht - J Damas - Corresponding author Published 09 August 2005 Received 25 January 2005 Journal of Inflammation 2005 2 9 doi 186 1476-9255-2-9 Accepted 09 August 2005 This article is available from http content 2 1 9 2005 Garbacki et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The effects of proanthocyanidins PACs isolated from blackcurrant Ribes nigrum L. leaves on neutrophil accumulation during inflammatory processes were investigated in vivo and in vitro. Methods In vivo studies were performed using carrageenin-induced pleurisy in rats pre-treated with PACs. Exudate volume and PMNs accumulation were measured. Leukocyte cell adhesion molecules LFA-1 Mac-1 and VLA-4 mobilization in circulating granulocytes were analysed by flow cytometry and endothelial cell adhesion molecules ICAM-1 and VCAM-1 were detected by immunohistochemistry on lung sections. In vitro studies were conducted .

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