tailieunhanh - Báo cáo y học: "Does carbon monoxide treatment alter cytokine levels after endotoxin infusion in pigs? A randomized controlled study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Does carbon monoxide treatment alter cytokine levels after endotoxin infusion in pigs? A randomized controlled study. | Journal of Inflammation BioMed Central Research Does carbon monoxide treatment alter cytokine levels after endotoxin infusion in pigs A randomized controlled study Anna-Maja Ảberg Pernilla Abrahamsson Goran Johansson Michael Haney Ola Winso and Jan Erik Larsson Open Access Address Division of Anaesthesiology and Intensive Care Medicine Department of Surgical and Perioperative Sciences Umeâ University Hospital Umeâ Sweden Email Anna-Maja Ảberg - Goran Johansson - Michael Haney - Ola Winso - Jan Erik Larsson - Corresponding author Published 7 August 2008 Received 28 February 2008 Journal of Inflammation 2008 5 13 doi 1476-9255-5-13 Accepted 7 August 2008 This article is available from http content 5 1 13 2008 Ảberg et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Carbon monoxide CO has recently been suggested to have anti-inflammatory properties but data seem to be contradictory and species-specific. Thus in studies on macrophages and mice pretreatment with CO attenuated the inflammatory response after endotoxin exposure. On the other hand human studies showed no effect of CO on the inflammatory response. Antiinflammatory efficacy of CO has been shown at concentrations above 10 carboxyhaemoglobin. This study was undertaken to elucidate the possible anti-inflammatory effects of CO at lower CO concentrations. Methods Effects of CO administration on cytokine TNF-alpha IL-6 IL-1beta and IL-10

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