tailieunhanh - Báo cáo y học: "Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. | Journal of Inflammation BioMed Central Research Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25 OH D concentrations in healthy women Catherine A Peterson and Mary E Heffernan Open Access Address Department of Nutritional Sciences University of Missouri-Columbia Columbia MO 65211 USA Email Catherine A Peterson - petersonca@ Mary E Heffernan - heffernanm@ Corresponding author tEqual contributors Published 24 July 2008 Journal of Inflammation 2008 5 10 doi 1476-9255-5-10 Received 1 November 2007 Accepted 24 July 2008 This article is available from http content 5 1 10 2008 Peterson and Heffernan licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Circulating 25 hydroxyvitamin D 25 OH D an accurate measure of vitamin D status is markedly greater in individuals with increased exposure to ultraviolet B UVB light via sunlight or the use of artificial UV light. Aside from the known relationship between vitamin D and bone vitamin D has also been implicated in immune function and inflammation. Furthermore a mass of evidence is accumulating that vitamin D deficiency could lead to immune malfunction. Our overall objective was to study the relationship between vitamin D status as determined by serum 25 OH D concentrations and inflammatory markers in healthy women. Methods This observational study included 69 healthy women age 25-82 years. Women with high UVB exposure and women with minimal UVB exposure were specifically recruited to obtain a wide-range of serum 25 OH D concentrations. Health sun exposure and habitual dietary intake information were obtained from all subjects. Body composition was determined by .