tailieunhanh - Báo cáo y học: "JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin. | Journal of Inflammation BioMed Central Open Access JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin Hye Ji Park 1 Hwa Jeong Lee1 Myung Sook Choi1 Dong Ju Son1 Ho Sueb Song2 Min Jong Song3 Jeong Min Lee4 Sang Bae Han1 Youngsoo Kim1 and Jin Tae Hong 1 Address College of Pharmacy Chungbuk National University 12 Gaesin-dong Heungduk-gu Cheongju Chungbuk 361-763 Korea 2College of Oriental Medicine Kyungwon University 65 Bukjeong-Dong Sujeong-gu Seongnam Gyeonggi 461-701 Korea 3Department of Obstetrics and Gynecology St. Vincent s Hospital The Catholic University Suwon 442-723 Korea and 4Life Science R D Center Sinil Pharmaceutical Co San 5-1 Bonpyung-Ri Angsung-Myun Chungju Chungbuk 380-862 Korea Email Hye Ji Park - lemondoll@ Hwa Jeong Lee - pure-cell@ Myung Sook Choi - dallll@ Dong Ju Son - sondj@ Ho Sueb Song - hssong70@ Min Jong Song - bitsugar@ Jeong Min Lee - jmlee777@ Sang Bae Han - shan@ Youngsoo Kim - youngsoo@ JinTae Hong - jinthong@ Corresponding author Published 29 May 2008 Received 14 March 2007 Journal of Inflammation 2008 5 7 doi 186 1476-9255-5-7 Accepted 29 May 2008 This article is available from http content 5 1 7 2008 Park et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bee venom therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. We previously found that bee venom and melittin a major component of bee venom have anti-inflammatory effect by reacting with the sulfhydryl group of p50 .