tailieunhanh - Báo cáo y học: " CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection. | Journal of Inflammation BioMed Central Research Open Access CXCR2 is critical for dsRNA-induced lung injury relevance to viral lung infection Vedang A Londhe1 John A Belperio2 Michael P Keane2 Marie D Burdick2 Ying Ying Xue2 and Robert M Strieter 1 2 3 Address Department of Pediatrics David Geffen School of Medicine at UCLA Los Angeles CA USA 2Division of Pulmonary and Critical Care Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA and 3Department of Pathology and Laboratory Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA Email Vedang A Londhe - vlondhe@ John A Belperio - jbelperio@ Michael P Keane - mkeane@ Marie D Burdick - mburdick@ Ying Ying Xue - yyxue@ Robert M Strieter - rstrieter@ Corresponding author Published 28 May 2005 Received 02 December 2004 Journal of Inflammation 2005 2 4 doi 1476-9255-2-4 Accepted 28 May 2005 This article is available from http content 2 1 4 2005 Londhe et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Respiratory viral infections are characterized by the infiltration of leukocytes including activated neutrophils into the lung that can lead to sustained lung injury and potentially contribute to chronic lung disease. Specific mechanisms recruiting neutrophils to the lung during virus-induced lung inflammation and injury have not been fully elucidated. Since CXCL1 and CXCL2 3 acting through CXCR2 are potent neutrophil chemoattractants we investigated their role in dsRNA-induced lung injury where dsRNA Poly IC is a well-described synthetic agent mimicking acute viral infection. Methods We used 6-8 week old