tailieunhanh - Báo cáo y học: "Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor. | Journal of Inflammation BioMed Central Research Open Access Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor Katharine C DeGeorge1 Brent R DeGeorge Jr2 James S Testa3 and Jay L Rothstein 1 4 Address Department of Immunology and Microbiology Otolaryngology-Head Neck Surgery Kimmel Cancer Institute Thomas Jefferson University Philadelphia Pennsylvania PA 19107 USA 2Center for Translational Medicine Department of Medicine Thomas Jefferson University Philadelphia Pennsylvania PA 19107 USA 3Department of Microbiology and Immunology Kimmel Cancer Institute Thomas Jefferson University Philadelphia Pennsylvania PA 19107 USA and 4Amgen Inc. Seattle Washington USA Email Katharine C DeGeorge - Brent R DeGeorge - James S Testa - Jay L Rothstein - jrothste@ Corresponding author Published 27 February 2008 Received 13 September 2007 Accepted 27 February 2008 Journal of Inflammation 2008 5 3 doi 186 1476-9255-5-3 This article is available from http content 5 1 3 2008 DeGeorge et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Farnesyltransferase inhibitors FTI are small molecule agents originally formulated to inhibit the oncogenic functions of Ras. Although subsequent analysis of FTI activity revealed wider effects on other pathways the drug has been demonstrated to reduce Ras signaling by direct measurements. The purpose of the current study was to determine if FTI could be used to inhibit the inflammatory activities of a known Ras-activating human oncoprotein RET PTC3. RET PTC3 is a fusion oncoprotein expressed in the thyroid epithelium of

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