tailieunhanh - Báo cáo y học: "Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease? | Journal of Inflammation BioMed Central Open Access Does CD4 CD25 foxp3 cell Treg and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome IRIS in HlV disease Esaki Muthu Shankar Ramachandran Vignesh Vijayakumar Velu Kailapuri G Murugavel Ramalingam Sekar Pachamuthu Balakrishnan Charmaine AC Lloyd Shanmugam Saravanan Suniti Solomon and Nagalingeswaran Kumarasamy Address YRG Centre for AIDS Research and Education VHS Hospital Campus Rajiv Gandhi Salai-Information Technology Corridor Taramani Chennai 600 113 India Email Esaki Muthu Shankar - shankarem@ Ramachandran Vignesh - vignesh@ Vijayakumar Velu - vvjai2000@ Kailapuri G Murugavel - murugavel@ Ramalingam Sekar - sekar@ Pachamuthu Balakrishnan - bala@ Charmaine AC Lloyd - charmaine@ Shanmugam Saravanan - saravanan@ Suniti Solomon - suniti@ Nagalingeswaran Kumarasamy - kumarasamy@ Corresponding author Published 18 February 2008 Received 26 November 2007 Accepted 18 February 2008 Journal of Inflammation 2008 5 2 doi l476-9255-5-2 This article is available from http content 5 1 2 2008 Shankar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ HIV-specific T-lymphocyte responses that underlie IRIS are incomplete and largely remain hypothetical. Of the several mechanisms presented by the host to control host immunological damage Treg cells are believed to play a critical role. Using the available experimental evidence it is proposed that enormous synthesis of conventional FoxP3- Th cells responsive often renders subjects inherently