tailieunhanh - Báo cáo hóa học: " Drug-eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Drug-eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection | Gulati et al. Nanoscale Research Letters 2011 6 571 http content 6 1 571 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Drug-eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection Karan Gulati Moom Sinn Aw and Dusan Losic Abstract Current bone fixation technology which uses stainless steel wires known as Kirschner wires for fracture fixing often causes infection and reduced skeletal load resulting in implant failure. Creating new wires with drug-eluting properties to locally deliver drugs is an appealing approach to address some of these problems. This study presents the use of titanium Ti wires with titania nanotube TNT arrays formed with a drug delivery capability to design alternative bone fixation tools for orthopaedic applications. A titania layer with an array of nanotube structures was synthesised on the surface of a Ti wire by electrochemical anodisation and loaded with antibiotic gentamicin used as a model of bone anti-bacterial drug. Successful fabrication of TNT structures with pore diameters of approximately 170 nm and length of 70 pm is demonstrated for the first time in the form of wires. The drug release characteristics of TNT-Ti wires were evaluated showing a two-phase release with a burst release 37 and a slow release with zero-order kinetics over 11 days. These results confirmed our system s ability to be applied as a drug-eluting tool for orthopaedic applications. The established biocompatibility of TNT structures closer modulus of elasticity to natural bones and possible inclusion of desired drugs proteins or growth factors make this system a promising alternative to replace conventional bone implants to prevent bone infection and to be used for targeted treatment of bone cancer osteomyelitis and other orthopaedic diseases. Keywords Kirschner wires titanium wires titania nanotubes bone fixation bone infection gentamicin Introduction Kirschner wires K-wires