tailieunhanh - Báo cáo khoa hoc:" Transcranial magnetic stimulation, synaptic plasticity and network oscillations"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Transcranial magnetic stimulation, synaptic plasticity and network oscillations | Journal of NeuroEngineering and Rehabilitation BioMed Central Open Access Review Transcranial magnetic stimulation synaptic plasticity and network oscillations Patricio T Huerta and Bruce T Volpe Address Weill Medical College at Cornell University Department of Neurology and Neuroscience Burke Cornell Medical Research Institute 785 Mamaroneck Ave White Plains NY 10605 USA Email Patricio T Huerta - Bruce T Volpe - btv3@ Corresponding author Published 2 March 2009 Received 25 February 2009 Journal of NeuroEngineering and Rehabilitation 2009 6 7 doi 86 1743-0003-6-7 Accepted 2 March 2009 This article is available from http content 6 1 7 2009 Huerta and Volpe licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Transcranial magnetic stimulation TMS has quickly progressed from a technical curiosity to a bona-fide tool for neurological research. The impetus has been due to the promising results obtained when using TMS to uncover neural processes in normal human subjects as well as in the treatment of intractable neurological conditions such as stroke chronic depression and epilepsy. The basic principle of TMS is that most neuronal axons that fall within the volume of magnetic stimulation become electrically excited trigger action potentials and release neurotransmitter into the postsynaptic neurons. What happens afterwards remains elusive especially in the case of repeated stimulation. Here we discuss the likelihood that certain TMS protocols produce longterm changes in cortical synapses akin to long-term potentiation and long-term depression of synaptic transmission. Beyond the synaptic effects TMS might have consequences on other neuronal processes such as .